HDAC5 antibody (AA 350-450)

Catalog No. ABIN6141677

This Rabbit Polyclonal antibody specifically detects HDAC5 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for HDAC5 antibody (AA 350-450) (ABIN6141677)

Target: HDAC5 (Histone Deacetylase 5 (HDAC5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC5 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-HDAC5 Antibody

Binding Specificity: AA 350-450

Sequence: RALPLDSSPN QFSLYTSPSL PNISLGLQAT VTVTNSHLTA SPKLSTQQEA ERQALQSLRQ GGTLTGKFMS TSSIPGCLLG VALEGDGSPH GHASLLQHVL L

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human HDAC5 (NP_005465.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:20 - 1:50

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HDAC5

Target: HDAC5 (Histone Deacetylase 5 (HDAC5))

Alternative Name: HDAC5

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.,HDAC5,HD5,NY-CO-9,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,G1/S Checkpoint,Notch Signaling Pathway,Wnt/β-Catenin Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Stem Cells,Cardiovascular,Heart,Hypertrophy,HDAC5

Molecular Weight: 112 kDa/121 kDa/122 kDa

Gene ID: 10014

UniProt: Q9UQL6

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Monocarboxylic Acid Catabolic Process